OUR APPROACH - Xinyu Zhao Neuroscience Laboratory at Tsinghua University's Site on Strikingly

OUR APPROACH

We believe in question-oriented research.

We strongly believe in the combination of experimental and computational studies.

Our lab supports a wide range of technologies to advance our understanding of learning.

Virtual Reality Behavior System (combined with Electrophysiology)

Silicon probe array implant

Zhao et al. Nature Neuroscience 2020

In-vivo Patch-Clamp and Rapid Plasticity

Zhao et al. Neuron 2022

VR-Ephys Rigs

Silicon

Triggered plateau potential converted a silent hippocampal cell into a behaviour-dependent place cell (green: current inject to trigger plateau potentials).
OUR PUBLICATIONS

On learning mechanisms:

1. Zhao X*, Hsu CL*and Spruston N. Rapid synaptic plasticity contributes to a learned conjunctive code of position and choice-related information in the hippocampus. Neuron,2022, 110:96-108

2. Zhao X, Wang Y, Spruston N & Magee J. Membrane potential dynamics underlying context-dependent sensory responses in the hippocampus. Nature Neuroscience,2020, 23(5):881-891

3. WeinanSun*,Xinyu Zhao*,Nelson Spruston. Bursting potentiates the neuro–AI connection, Nature Neuroscience,2021, 24: 905-906

4. Ching-LungHsu, XinyuZhao, Aaron Milstein, Nelson Spruston.Persistent Sodium Current Mediates the Steep Voltage Dependence of Spatial Coding in Hippocampal Pyramidal Neurons, Neuron,2018, 99(1): 147-162

On visual processing:

1. Zhao X*, Liu M* and Cang J. Visual Cortex Modulates the Magnitude but Not the Selectivity of Looming-Evoked Responses in the Superior Colliculus of Awake Mice. Neuron,2014, 84(1):202-21

2. Zhao X, Chen H, Liu X and Cang J. Orientation-selective Responses in the Mouse Lateral Geniculate Nucleus. Journal of Neuroscience, 2013, 33(31):12751-63

3. Zhao X, Liu M and Cang J. Sublinear binocular integration preserves orientation selectivity in mouse visual cortex. NatureCommunications, 2013, 4:2088